In this review, we introduce how fibrotic stroma interacts with tumor cells in different organs: (1) the interplay between fibrotic stroma and cancer cells via metabolic manners; (2) how signaling mediates features of fibronectin (FN) and enzymes regulating collagen exert a protumor effect; (3) robust reciprocal communications between cancer cells and CAFs mediated by secretory molecules; (4) demonstration of the pro-inflammatory feature of CAFs and the controversial involvement of ECM in tumor immunity. Here, FN1 is linked to cancer.