Next, we focus on demonstrating the potential role of different signaling pathways including mammalian target of rapamycin (mTOR), Wnt, and Notch and molecules including non-coding RNA (ncRNA), fumarate hydratase (FH), and other molecules, promoting both renal fibrosis and RCC, which hopefully may provide valid insights for future studies regarding the correlation between these two pathogeneses. The gene discussed is FH; the disease is renal fibrosis.