ANGPT1 and acute myeloid leukemia: Tie2 is frequently overexpressed in AML, including on leukemic blasts themselves, whilst both Ang-1 and Ang-2 are overexpressed in BM and patient serum in some AML patients (Müller et al., 2002; Watarai et al., 2002; Schliemann et al., 2006, 2007).