Tie2 is frequently overexpressed in AML, including on leukemic blasts themselves, whilst both Ang-1 and Ang-2 are overexpressed in BM and patient serum in some AML patients (Müller et al., 2002; Watarai et al., 2002; Schliemann et al., 2006, 2007). The gene discussed is TEK; the disease is acute myeloid leukemia.