CD34 and myelodysplastic syndrome: Interestingly, normal CD34+ cord blood HSPCs co-cultured with MDS-derived (versus healthy control) ECFCs displayed markedly reduced proliferation and multilineage differentiation potential, associated with aberrant expression of key genes associated with granulomonocytic and erythroid differentiation, including SPI1, MPO, TFR, and GPIb (Teofili et al., 2015).