Thus targeting the IL-8/CXCR1/CXCR2 axis might be another promising avenue for clinical exploration in AML, as well as other myeloid malignancies in which high IL-8 expression has been pathologically implicated, including MDS (Shi et al., 2019), CMML (Niyongere et al., 2018), and myelofibrosis (Tefferi et al., 2011). This evidence concerns the gene CXCL8 and chronic myelomonocytic leukemia.