EGF has also been described to induce EMT in different model systems like colon cancer (Sakuma et al., 2012) and mesothelioma cell lines (Schelch et al., 2018b), and was reported to cooperate with TGFβ for EMT induction (Docherty et al., 2006; Uttamsingh et al., 2008). This evidence concerns the gene EGF and colonic neoplasm.