Recently, Barkal et al. (2019) have shown that tumor-expressed CD24 binds macrophage sialic-acid-binding Ig-like lectin 10 (Siglec-10) to promote tumor avoidance in the tumor microenvironment by recruiting SHP2 to the cytoplasmic tail ITIM motif of Siglec-10. The gene discussed is PTPN11; the disease is neoplasm.