Multiple researches reported that GOF mutations SHP2D61G and SHP2E76K are related to MPN (Xu et al., 2010), NS (De Rocca Serra-Nédélec et al., 2012), or JMML (Yang et al., 2008) through activation of Ras/Erk signaling in vivo and in vitro. This evidence concerns the gene PTPN11 and myeloproliferative disorder.