SHP2E76K activation mutation in bone marrow mesenchymal stromal cells (BMSCs) upregulates vascular cell adhesion molecule 1 (VCAM-1) expression by increasing the PI3K/Akt phosphorylation level and further induces BMSC-mediated chemoresistance in B-cell acute lymphoblastic leukemia (B-ALL) (Yu et al., 2020). The gene discussed is VCAM1; the disease is precursor B-cell acute lymphoblastic leukemia.