Mutations in SALL4 are associated with Duane-radial ray syndrome/Okihiro syndrome and SALL4-related Holt-Oram syndrome, both of which show phenotypes similar to those of thalidomide embryopathy (Al-Baradie et al., 2002; Kohlhase et al., 2002, 2003). The gene discussed is SALL4; the disease is Holt-Oram syndrome.