With respect to cancer, overexpression of HMGR by activation of the gene for the sterol regulatory element binding protein (SREBP) is not fully understood (Brown and Goldstein, 1980; Porstmann et al., 2005; Goldstein et al., 2006), but a close interrelationship between SREBP and cancer’s clinical hallmarks has been described (Bao et al., 2016). The gene discussed is CNBP; the disease is cancer.