HMGA1 and neoplasm: In terms of the generally protracted time-line of tumor cell growth, therefore, accumulated data accentuate these tightly linked metabolic hallmarks of uncontrolled cell proliferation: deregulation of cholesterogenesis at the HMGR metabolic locus; mitochondrial membrane enrichment with cholesterol; preferential export of pyruvate-generated (glycolysis-generated) citrate from cholesterol-enriched mitochondria; and the requirement of a continual supply of mevalonate for ensuing DNA synthesis and cell replication.