Using the specific CTP inhibitor, 1,2,3-benzenetricarboxylate (BTC), Kaplan et al. (1982) completed the first comprehensive study on the kinetic characteristics of CTP exchange transport in tumor vs. normal mitochondria, demonstrating that a highly probable positive correlation exists between cholesterol enrichment of tumor mitochondria and an increased Vmax for citrate transport displayed by the CTP. Here, SLC25A1 is linked to neoplasm.