AQP1 and esophageal squamous cell carcinoma: We recently demonstrated the induction of apoptosis in ESCC cells by the genetic knockdown of AQP1 with siRNA technology, alterations in Death receptor signaling pathway-related genes in AQP1-depleted TE5 cells by a microarray analysis, and a correlation between the cytoplasmic dominant expression of AQP1 and a poor prognosis in patients with ESCC by IHC (Yamazato et al., 2018).