ITGAM and neoplasm: In tumor tissues, IL-35 involved in JAK/STAT pathway phosphorylation by recruiting bone marrow-derived CD11b+Gr1+ inhibitory effector cells, which then promoted the tumor angiogenesis and immunosuppression of the tumor microenvironment (Facciabene et al., 2012; Liang et al., 2016; Long et al., 2016; Turnis et al., 2016).