Secretion of IL-35 by liver tumor cells has been reported to associate with IL-35 up-regulation via a positive feedback, inhibition of proliferation, activation, cytotoxicity of CD8+ T cells that promoted disease progression, and viral gene mutation and induction of tumor immune escape (Qiu et al., 2016; Damo and Joshi, 2019; Xue et al., 2019). This evidence concerns the gene CD8A and neoplasm.