In a rodent lung lipopolysaccharide inflammation model, breast cancer lung metastasis was significantly increased via E-selectin upregulation in the lung endothelium (Jiang et al., 2014) probably through the production of pro-inflammatory cytokine TNF-α (Eichbaum et al., 2011), which can upregulate several adhesion molecules on endothelial cells and promote metastatic cell adhesion and migration (Mannel et al., 1994; Stoelcker et al., 1995), including E-selectin, P-selectin, ICAM-1, and VCAM-1. This evidence concerns the gene SELE and breast carcinoma.