Their results further revealed that the recruitment of MDA-MB-231 breast cancer cells is mediated by the CXCR4 receptor on endothelial cells and is independent of the CXCL12 level on the breast cancer cells, suggesting the potential of CXCL12-CXCR4 inhibition as a valid therapeutic target for preventing metastasis. Here, CXCR4 is linked to breast carcinoma.