Neutrophils in periodontitis also have a higher cytokine reactivity as the expression of chemokines and the release of cytokines (IL-1β, IL-6, IL-8, and TNF-α) are higher in neutrophils isolated from late-onset periodontitis patients (Lakschevitz et al., 2013; Ling et al., 2015). This evidence concerns the gene TNF and periodontitis.