However, during periodontitis, the immune response is a double-edged sword because the cytokines and antimicrobial components produced during the immune response, such as IL-17, IL-6, IL-1β, TNF-α, ROS, and NETs, can induce bone resorption and soft tissue injury (Ramadan et al., 2020; Magan-Fernandez et al., 2020). This evidence concerns the gene IL1B and periodontitis.