exhibited a significant relationship between TLR2 SNPs and susceptibility to non-HIV cryptococcal meningitis (CM) and found that non-HIV CM patients carrying the TLR2 rs3804099 C/T genotype had significantly lower levels of 12 cerebrospinal fluid (CSF) cytokines, predominantly proinflammatory cytokines and chemokines, suggesting that the rs3804099 C/T genotype may downregulate immune responses (Jiang et al., 2018). This evidence concerns the gene TLR2 and Cryptococcal meningitis.