The results showed that CD8A, CD8B, CD2, CD3E, CD3E, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL2, KIR2DS4, CD11b, T-bet, STAT6, STAT5A, BCL6, STAT3, CTLA4, LAG3 and TIM-3 had a significant association with SLC1A4 expression level in tumor tissue from HCC patients. The gene discussed is LAG3; the disease is hepatocellular carcinoma.