And the GSEA analysis indicated that ubiquitin-mediated proteolysis, cell cycle, purine metabolism, basal transcription factors, pancreatic cancer, lysosome, prostate cancer, oocyte meiosis, pathways in cancer, small cell lung cancer, RNA degradation and insulin signaling pathway were enrichment in SLC1A4 high-expressed group (Figure 4H). Here, INS is linked to familial pancreatic carcinoma.