To further validate that ZNF213 is relevant for endocrine resistance, MCF-7 and T47D cells were treated with the indicated tamoxifen concentrations, we found that ZNF213 depletion sensitized tamoxifen inhibition effect in MCF-7 and T47D breast cancer cells (Figure 2D, Figure S1D). The gene discussed is ZNF213; the disease is breast carcinoma.