In KRAS/p53 mutant murine lung cancer models neurotrophic receptor tyrosine kinase 1 (NTRK1) has been found to be upregulated after treatment with PD-1 inhibitors and to regulate JAK/STAT signaling, promoting PD-L1 expression and CD8+ T cell exhaustion in the microenvironment. The gene discussed is NTRK1; the disease is lung cancer.