UBR5 and familial pancreatic carcinoma: Then we focused on pancreatic cancer and found that the UBR5 mRNA expression was remarkably increased in pancreatic cancer tissues compared with noncancerous pancreatic tissues based on the RNA-seq data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases, as well as the microarray-based gene expression profiles (GSE16515 and GSE15471) from GEO database (Figures 1A,B).