Conversely, overexpression of UBR5 in MIA PaCa-2 and BxPC-3 cells (Figure 2F), which had relatively low intrinsic expression of UBR5 among the five tested pancreatic cancer cell lines (Figures 2A,B), significantly enhanced their migratory and invasive ability in vitro (Figures 2G,H), indicating that UBR5 could promote the migration and invasion of pancreatic cancer cells. The gene discussed is UBR5; the disease is familial pancreatic carcinoma.