Consistent with the observation that UBR5 was upregulated in pancreatic cancer tissues, all five pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, MIA PaCa-2, and PANC-1) we tested exhibited significantly higher UBR5 expression at both mRNA and protein levels than the normal human pancreatic duct epithelial hTERT-HPNE cells (Figures 2A,B). Here, UBR5 is linked to familial pancreatic carcinoma.