HAO1 and acute myeloid leukemia: Using metabolomic profiling of AML cell lines (in which ROS production was inhibited by knocking down NOX2 expression) or using a cell line incubated with glucose oxidase (GOX; an enzyme that produces H2O2), we report significant metabolic alterations in sphingolipid metabolism, fatty acid oxidation (FAO), purine metabolism, amino acid homeostasis and glycolysis.