Again, NK cells co-cultured with cancer cells in the presence IL-15 combined with ADU-S100 analog expressed the highest amounts of CD69 (a mean of 54 and 57% respectively for LNCaP and PC3 co-cultures respectively, compared to a mean of 25 and 33% expression for LNCaP and PC3 co-cultures respectively, with IL-15 alone and 23 and 44% for LNCaP and PC3 co-cultures respectively, with ADU S-100 analog alone (Figure 4A). The gene discussed is CD69; the disease is cancer.