In this study we sought to investigate whether a combination of IL-15 and ADU-S100 analog [2 ́3 ́-c-di-AM(PS)2 (Rp,Rp)] could lead to an increased therapeutic potential in targeting prostate cancer using in an in-vitro prostate cancer-lymphocyte co-culture model, and if so, which are the main immune cell populations involved in the eradication of the cancer cells. This evidence concerns the gene IL15 and cancer.