IFNG and neoplasm: We hypothesized that IL-15 could induce tumor cell death by increasing the activation and proliferation of NK cells through upregulation of type II interferons (IFNs) i.e. IFNγ, while ADU-S100 analog could activate type I interferons i.e. IFNα/β on effector cells, as previously shown in T cells (26) hence combining the two agents could lead to an augmented effect.