Finally, this study also confirmed that exosomes could protect lncRNAs from degradation caused by RNase A and make lncRNAs stable in serum, thus suggesting that exosomal lncRNAs FOXD2-AS1, NRIR, and XLOC_009459 could serve as non-invasive tumor markers for CRC diagnosis and early-stage CRC patients. Here, FOXD2 is linked to neoplasm.