Among them, 16 lncRNAs with the most significance were selected including 7 upregulated genes (FOXD2-AS1, NRIR, XLOC_009459, MIAT, LINC001481, AP000892.4, FAM197Y9) and 9 downregulated genes (DICER1-AS1, LINC00570, MIRLET7BHG, LINC00885, HOTAIR, AC012456.3, DSCAM-AS1, MIR503HG, POC1B), then subjected to primer design and specificity verification, and 8 of them were excluded due to poor primer specificity; others were subjected to a cohort with 48 healthy people and 48 CRC patients, and 5 of them were excluded due to no difference. The gene discussed is POC1B; the disease is colorectal carcinoma.