High grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBL-DHL), formerly termed double-hit lymphoma (DHL) which constitutes 5–10% of histologically diagnosed diffuse large B-cell lymphoma (DLBCL), is currently classified as a unique and separate entity (1, 2). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.