Importantly, VDAC acts as a main gatekeeper in the outer mitochondrial membrane that mediates exchange of principal metabolites and ions between mitochondria and cytosol [(143), discussed in Metabolic Re-programming and Upregulation of the PI3K/Akt/mTOR Pathway Is Related to GC Resistance in ALL]. The gene discussed is AKT1; the disease is acute lymphoblastic leukemia.