Besides stimulation with cytokines (such as IL-12, IL-15 or IL-2, discussed below), the anti-tumor effects of endogenous NK cells can be stimulated by administration of bispecific and trispecific killer cell engagers (BiKE and TriKE, respectively), constituted by antibodies targeting CD16 or NKG2D and one or two tumor antigens (61). Here, KLRK1 is linked to neoplasm.