Eosinophils are recruited from the blood into the sites of inflammation where, upon activation, they can release an array of inflammatory mediators such as for example cationic proteins (major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxide (EPX), and eosinophil-derived neurotoxin (EDN)) that are unique to eosinophils and are important in the defense against parasitic infections (90). This evidence concerns the gene RNASE3 and parasitic infectious disease.