Notably, chemokines such as CCL2, CCL5, CCL17, CCL18, CCL20 and CCL22, cytokines such as hepatocyte growth factor (HGF), PDGF-B, VEGF, IL-4, IL-10, prostaglandin (PG) and TGF-β and enzymes, such as Cathepsin K, cyclooxygenase-2 (COX-2), ARG1 and MMPs secreted by TAMs can directly inhibit both CD8+ and CD4+ T cell effector function as well as recruit Tregs into the tumor lesion (114). Here, CD4 is linked to neoplasm.