The non-immune role of TAMs consists in the release of numerous angiogenic factors, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF), that stimulate angiogenesis within the tumor, as well as in the secretion of many signaling molecules, including EGF, matix metalloproteinases (MMPs), CCL2, CCL18, and macrophage (M)-CSF that consequently activate tumor cell epithelial–mesenchymal transition (EMT), invasion, and metastasis (34, 35). Here, CCL2 is linked to neoplasm.