After the establishment of a new lung cancer model in mice and the collection of tumor tissues (Figure 7A), the tumor weight (Figure 7B) was decreased by PD-L1 inhibitor (Anti-PD-L1) (P < 0.001) and shCircCHST15 (P < 0.001) when compared with the Control group and the mock group, respectively, but the tumor weight was increased by CircCHST15 (P < 0.001) when compared with the mock group. This evidence concerns the gene CD274 and lung cancer.