As for the T cell subtype (Figures 7C–H), consistent with the results in Figure 2, the CD4+ T cells in the blood (Figures 7C, I, J) and tumor (Figures 7D, I, J) among these group showed no changes, but the CD8+ T cells and Tregs in the blood (Figures 7E, G, I, J) were decreased in the Control group (P < 0.05) and in the CircCHST15 group (P < 0.05), and increased by Anti-PD-L1 (P < 0.001) and shCircCHST15 (P < 0.01). Here, CD4 is linked to neoplasm.