Then the T cell subtype in the blood of mice and the tumor supernatant was analyzed, and the data revealed that the percentage of CD4+ T cells in the blood and tumor had no changes among all the groups (Figures 2C, D, I, J), while the percentage of CD8+ T cells in the blood of the control mice was reduced compared with the NC group (P < 0.001, Figures 2E, I, J) and increased by shCircCHST15 both in the blood (Figures 2E, I, J) and tumor supernatant (Figures 2F, I, J) when compared with the mock group (P < 0.01). This evidence concerns the gene CD4 and neoplasm.