Hsa_circ_0052112 sponges miR-125-5p to promote breast cancer cell migration (23); has_circ_0078710 participates in the progression of liver cancer by sponging miR-31 (24); hsa_circ_0012919 sponges miR-125a-3p to promote the progression of DNA methylation of CD11a in T cells (25). This evidence concerns the gene ITGAL and breast cancer.