Compared with the mutated genes identified in the pBC (Figure 5A), ESR1, ARID2, BLM, FGFR4, APC, ERBB2, ROS1, ATR, IGF1R, NF1, JAK1, FAT1, NOTCH2, and AKT1 mutation frequencies were significantly different in LM. This evidence concerns the gene ESR1 and lymphangioma.