Compared with the mutated genes identified in the pBC (Figure 5A), ESR1, ARID2, BLM, FGFR4, APC, ERBB2, ROS1, ATR, IGF1R, NF1, JAK1, FAT1, NOTCH2, and AKT1 mutation frequencies were significantly different in LM. The gene discussed is APC; the disease is lymphangioma.