Huang et al. conducted a comprehensive analysis of the methylation status of 4 genes, including APC, GSTP1, RASSF1A, and SFRP1. The results showed that the methylation status of 4 genes from the HC group identified an AUC of HCC of 0.933, while the AUC of a single gene was 0.800–0.881. This evidence concerns the gene GSTP1 and hepatocellular carcinoma.