The combination of AFP and exosomal miR-21-5p and miR-92a-3p in a logistic regression equation for early screening of HCC, and the AUC for the combination of AFP and exosomal miR-21-5p and miR-92a-3p was 0.85, significantly better than serum AFP alone. The gene discussed is AFP; the disease is hepatocellular carcinoma.