Using cfDNA samples from 1,098 HCC patients and 835 HC patients, Xu et al. identified an HCC-specific methylation marker panel (BMPR1A, PSD, ARHGAP25, KLF3, PLAC8, ATXN1, Chr 6:170, Chr 6:3, ATAD2, Chr 8:20). Here, ATXN1 is linked to hepatocellular carcinoma.