The AUC for the combination of lncRNAs (ENSG00000258332.1 and LINC00635) and AFP was 0.894 (83.6% sensitivity and 87.7% specificity), and exosomal ENSG00000258332.1 and LINC000635 were positively correlated with lymph node metastasis, TNM stage and overall survival in HCC patients. The gene discussed is AFP; the disease is hepatocellular carcinoma.