Circ_104075 showed better diagnostic performance compared with AFP (AUC value: 0.726), des-gamma-carboxyprothrombin (DCP) (AUC value: 0.771), Lens culinaris agglutinin-reactive AFP (AUC value: 0.766), lncRNA, and miRNA biomarkers such as DANCR (AUC: 0.851), miR-223 (AUC: 0.818), miR-21 (AUC: 0.782), and UCA1 (AUC: 0.735); and study showed that the high serum expression of circ_104075 was specific to HCC, so that the circulating circ_104075 can be used as a promising diagnostic biomarker for the early diagnosis of HCC (114). Here, AFP is linked to hepatocellular carcinoma.