Compared with normal tissues, BCL2, ULK3, DAPK2, CAPN2, CASP1, DAPK1, CASP3, RAF1, HDAC1, PRKAB1, and MTMR14 are lowly expressed in CRC, and BAG3, BID, BIRC5, and MYC are highly expressed. The gene discussed is PRKAB1; the disease is colorectal carcinoma.