We find that BCL2, ULK3, DAPK2, CAPN2, CASP1, DAPK1, CASP3, RAF1, HDAC1, PRKAB1, and MTMR14 were lowly expressed in CRC, and BAG3, BID, BIRC5, and MYC were highly expressed. The gene discussed is CASP1; the disease is colorectal carcinoma.