Indeed, the prediction model learning to 10 years follow-up reached an AUC value of 91.20%, an accuracy of 80.39%, a sensitivity of 95.83%, and a specificity of 66.67% with only five features, i.e. Carcinoma In Situ associated with invasive component, Vascular Invasion, ER, ki67 and type of Surgery selected by RF technique. This evidence concerns the gene MKI67 and carcinoma.