GPT and anemia (phenotype): In rats, the oral or intramuscular administration of DSS for 2–24 weeks (0.25−40 mg/kg/day) resulted in GI toxicity, lymph node hypertrophy and hyperplasia, and anemia as well as changes in hepatic or renal function parameters (aspartate aminotransferase [AST], alanine aminotransferase [ALT], Alkaline phosphatase [AP], or blood urea nitrogen [BUN]) [1,[12], [13], [14]].