At present, several alterations of glycolytic related molecules have been reported in CCA such as glucose transporters (GLUT) hexokinase (HK) II (Paudyal et al., 2008; Thamrongwaranggoon et al., 2017), and Tumor M2-pyruvate kinase (PKM2) (Cuenco et al., 2018). This evidence concerns the gene PKM and cholangiocarcinoma.