Furthermore, this is highly expressed in the liver, kidneys and intestines, but is downregulated in the pancreas, stomach and epididymis in adult vertebrates (Odom et al., 2004; Tanaka et al., 2006).In the study of hepatic fibrosis, it was found that the progression of hepatic fibrosis was correlated to the decreased expression of Hnf4α. The gene discussed is HNF4A; the disease is Hepatic fibrosis.