AKT1 and renal fibrosis: Furthermore, in vivo and in vitro evidences have suggested that DHA and Nrf2 may attenuate renal fibrosis through the regulation of fibroblast proliferation and differentiation by inhibiting the PI3K/AKT pathway, and both of these have been used as therapeutic antifibrotic targets for the treatment of renal fibrosis (Wang et al., 2019; Zhang et al., 2019).