Melatonin: comparably to BMP-5, melatonin stimulation resulted in aggravation of AKI in the “IRI + MV + Mela” group (IRI + MV + Mela vs. IRI 872 ± 34 vs. 696 ± 26 ng/ml; p=0.0007). This evidence concerns the gene BMP5 and acute kidney injury.