CST3 and ischemia: Whereas native SECR or SECR/MV in combination did not improve kidney function after ischemia (671 ± 26 and 630 ± 25 vs. 696 ± 26 ng/ml; p=0.5 and p=0.08), MV derived from unstimulated cells significantly lowered serum cystatin C levels (593 ± 17 vs. 696 ± 26 ng/ml; p=0.004).