Our results showed that ZSD treatment led to a dramatic decrease in the transcription of PI3K, AKT, and β-catenin (p < 0.05, p < 0.01; Figure 5(d)) and an increase in that of caspase-3, Bax, and GSK-3β (p < 0.01, p < 0.001). This evidence concerns the gene AKT1 and peroxisome biogenesis disorder.