CASP3 and peroxisome biogenesis disorder: Our results showed that the protein level of p-AKT, p-GSK-3β, β-catenin, and Bcl-2 was markedly reduced in H1299 cells with ZSD treatment for 12 h, 24 h, and 48 h, while the level of cleaved caspase-3 and Bax was evidently increased compared to the control group (p < 0.05, p < 0.01, and p < 0.001; Figure 6(a)).