Although the other 19 nodes (i.e., GATA2, ETS1,YBX1, AR, FOXP3, GATA1, SP1, E2F4, PRDM14, ARNT, MIA3, JUN, CREB1, FOS, STAT1, CEBPA, AHR, E2F1, PAX5, and Pax-5) except FOS were not differentially expressed in pulpitis, they still play critical roles in the pathogenesis of pulpitis by interacting and regulating DEGs that are expressed in pulpitis. The gene discussed is ETS1; the disease is pulpitis.