In the case of STAT1 (Signal Transducer And Activator Of Transcription 1), it has been shown to play a critical role in mediating the cellular responses to many inflammatory mediators involved in pulpitis, including interferons (IFNs), cytokines (IL1, IL6, and KITLG/SCF), and growth factors (epidermal growth factors (EGF) and platelet-derived growth factor (PDGF)) [83]. The gene discussed is STAT1; the disease is pulpitis.