Seven signaling pathways have been identified to be significantly enriched in the pathogenesis of pulpitis, for example, NOD-like receptor (NLR), Toll-like receptor (TLR), NF-kappa B, tumor necrosis factor (TNF), cell adhesion molecules (CAMs), chemokine, and cytokine-cytokine receptor interaction pathways. The gene discussed is TNF; the disease is pulpitis.