For example, IFN-gamma has been shown to be a feasible modulator to improve the dentinogenic and immunosuppressive functions of irreversible pulpitis-DPSCs [84]; cytokines as a crucial part of host response could be regarded as diagnostic markers of pulpal inflammation [85, 86]; and growth factors can contribute to the angiogenic response of pulp tissue and enhance the regeneration of pupal-like tissue [87, 88]. This evidence concerns the gene IFNG and inflammation.