AT-rich interaction domain 1A (ARID1A) is one of the major members of SWItch/Sucrose non-fermentable chromatin remodeling complexes, which is often found to be loss-of-function mutations in different types of cancer, such as non-small cell lung cancer (NSCLC) (40), breast cancer (BC) (41) and pancreatic ductal adenocarcinoma (PDAC) (42). The gene discussed is ARID1A; the disease is breast carcinoma.