Previous studies have reported that downregulating UCA1 expression can reverse drug resistance in cancers, and some drugs for chemotherapy exert an anticancer role by mediating UCA1 (Table IV), including cisplatin (70,81), tamoxifen (83), paclitaxel (128), 5-FU (22), Adriamycin (129), temozolomide (81), cetuximab (130), trastuzumab (131), imatinib (132), docetaxel (133) and gemcitabine (70). The gene discussed is UCA1; the disease is cancer.