The results showed that the levels of AGEs, IL-6, IL-8, TNF-α, and monocyte chemotactic protein-1 (MCP-1) in plasma of T2DM patients were significantly higher than those of the normal control group, indicating that there may be a relationship between AGEs and neuroinflammatory factors in T2DM. This evidence concerns the gene IL6 and type 2 diabetes mellitus.