Therefore, short-term, systemic delivery of CU-3, a selective inhibitor of diacylglycerol kinase alpha (DGKα) mediated PA biosynthesis, reduced MQs infiltration, inflammation, and MMP activity during the acute phase, and further mitigated left ventricular remodeling during the chronic phase in mouse MI [89]. The gene discussed is DGKA; the disease is myocardial infarction.