Increased intrahepatic levels of triglyceride (TG) induce the changes in hepatokine transcription and endoplasmic reticulum processing, leading to decrease the secretion of some hepatokines (such as sex hormone-binding globulin (SHBG), angiopoietin-like protein 4 (ANGPTL4), and adropin) during steatosis and increase the secretion of other hepatokines (such as fetuin-A, fetuin-B, hepassocin, leukocyte cell-derived chemotaxin 2 (LECT2), retinol-binding protein 4 (RBP4), and selenoprotein P (SeP)) [11]. The gene discussed is RBP4; the disease is steatosis.