Of the top 10 hub TFs, six “leader” immunosuppressive TF-target DEGs with plausible literature evidence were identified as key to periodontitis pathogenesis and included the down-regulated TFs (NFKB1, FOS, and JUN), as well as up-regulated TFs (HIF1A, STAT5B, and STAT4). This evidence concerns the gene NFKB1 and periodontitis.