Specifically, subtype S1 of immunosuppressive DEGs in periodontitis from both GSE16134 (Figure 5A) and GSE10334 (Figure 6A) was mainly enriched in cytokine-cytokine receptor interaction, chemokine signaling pathway, Janus kinase (JAK)- Signal Transducer and Activator of Transcription Protein (STAT) signaling pathway, Hypoxia-inducible Factor (HIF)-1 signaling pathway, and T cell receptor signaling pathway. Here, HIF1A is linked to periodontitis.