Perturbation of the cohesin loading factor NIPBL in both mouse and zebrafish results in multi-organ defects (including heart abnormalities) reminiscent to the Cornelia de Lange Syndrome, a congenital disease linked to NIPBL mutation (Kawauchi et al., 2009; Muto et al., 2011; Santos et al., 2016). Here, NIPBL is linked to Cornelia de Lange syndrome.