PURA first became a candidate for neurodevelopmental disorders when deletions of the genomic region 5q31.2–3, which includes the genes Neuregulin2 (Ring et al., 1999) and PURA (Ma et al., 1995), were reported to correlate with intellectual disability (ID) and other related symptoms (Shimojima et al., 2011; Hosoki et al., 2012). This evidence concerns the gene PURA and neurodevelopmental disorder.