BLM and neoplasm: BLM-depleted cells lead to amassment of damaged DNA, showed suppressed cell proliferation, and enhanced genomic damage with high response or sensitivity toward various chemotherapeutic drugs like cis-diamminedichloroplatinum (CDDP or cis-Pt), CPT, HU (Arora et al.), and 5-fluorouracil (5-FU) (Mao et al., 2010), suggesting its tumor-suppressive function.