Conditional BLM knockout mice bearing heat shock promoter cre transgene (HS-cre), prostate-specific antigen promoter-cre transgene (PSA-cre), and ovine beta-lactoglobulin promoter-cre transgene (BLG-cre) develop different types of mammary tumors, i.e., adeno-myoepithelioma and adenocarcinoma (Chester et al., 2006). The gene discussed is KLK3; the disease is adenocarcinoma.