TNF and cancer: The top five functional annotations were “PI3K-Akt signaling pathway” (P = 5.7E-4), “NF-kappa B signaling pathway” (P = 4.0E-3), “Transcriptional mis-regulation in cancer” (P = 5.2E-3), “TNF signaling pathway” (P = 8.2E-3), and “Insulin resistance” (P = 9.3E-3).