Pathway-based functional annotation was performed on the 117 nodes with a node degree ≥1 (i.e., with at least one physical interaction partner) in the “T1D-T2D islet eQTL interaction network.” The top canonical pathways based on IPA pathway analysis included “Cell Cycle: G1/S checkpoint regulation,” “PEDF Signaling,” “Osteoarthritis Pathway,” “Cell cycle control of chromosomal regulation,” and “RhoA signaling” (Figure 2C). This evidence concerns the gene RHOA and type 2 diabetes mellitus.