The representative terms and genes for these 3 clusters are “Signaling by NOTCH4” (with 6 genes involved: ACTA2, FBXW7, NOTCH2, PSMB1, PSMB8, PSMB9), “Apoptosis-related network due to altered Notch3 in ovarian cancer” (with 5 genes involved: APOE, AXIN1, ERBB3, ERN1, IL7R) and “Epstein-Barr virus infection” (with 35 genes involved: HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DRA, HLA-DRB5, ITGB3, TAP1, TAP2, TUBA4A, CIITA, IL2RA, IL7R, NOTCH2, RARA, PTPRN2, EEF1A2, SOCS1, ICAM1, KRT40, CEBPG, CTSD, LSP1, IKBKE, KPNA2, OAS3, ADCY5, CDKN2C, FOSL1, MYC, DDB2, TNFAIP3, RAC2, AP1B1, AP2M1, PSMB9). The gene discussed is HLA-DRB5; the disease is ovarian cancer.