Based on the GWASs and the following replication studies, the SNP rs2681472 of the ATP2B1 gene was confirmed to be associated with blood pressure or hypertension in various populations (Levy et al., 2009; Newton-Cheh et al., 2009; Hirawa et al., 2013; Kato et al., 2015; Nikpay et al., 2015; Liu et al., 2016; Nelson et al., 2017; Takeuchi et al., 2018). This evidence concerns the gene ATP2B1 and hypertensive disorder.