Moreover, combined analysis of the two largest cohorts, CHARGE and Global BPgen, further confirmed that only ATP2B1 variants were able to reach genome-wide significance (P < 5 × 10−8) with SBP (rs2681492), DBP (rs2681472) and hypertension (rs2681472) (Hirawa et al., 2013). Here, ATP2B1 is linked to hypertensive disorder.