ERCC2 and lung adenocarcinoma: The helicase ERCC2/XPD involved in DNA repair, the PHACTR2 protein that regulates the cytoskeleton, the DUSP1 protein that negatively regulates the MAP-kinase pathway are examples where SNPs have been identified (≈25% of cases) in lung adenocarcinoma (Spinola et al., 2007).