After searching in Pubmed, we found that the expression and function of LSP1 (Park et al., 2014), LY96 (Rajaraman et al., 2009), IFI30 (Liu et al., 2020; Zhu et al., 2020), and ARPC1B (Lauber et al., 2018) in GBM has been reported, and research about NPC2 in GBM are remain rescue. The gene discussed is NPC2; the disease is glioblastoma.