IRF5 and neoplasm: As exhibited in Figure 5B, the markers of B cell (CD19, CD79A), CD8 + T cell(CD8A, CD8B), M1 macrophages (PTGS2, IRF5), M2 macrophages (VSIG4, MS4A4A), neutrophil cells (ITGAM, CCR7), and myeloid dendritic cells (HLA-DPB1, HLA-DRA) all showed a significant positive correlation coefficient with NPC2, implicating potential role of NPC2 in tumor infiltration.