Similar to the CD38+HLA-DR+ cells, the expansion of PD-1+ cells varied widely, but importantly a strong positive correlation between CD38+HLA-DR+ cells and PD-1+ cells was observed in COVID-19 patients (Figure 2D), suggesting the possibility that PD-1 expression on CD4 T cells during acute SARS-CoV-2 infection is more an activation marker than an exhaustion marker. This evidence concerns the gene CD4 and COVID-19.