Sepsis, disseminated fungal or viral infections, hemophagocytic syndrome, hemorrhage (including intracranial, cerebral, and lung hemorrhage), multiple organ failure, pneumonia, pulmonary embolism, hepatitis, pulmonary hypertension, and disseminated intravascular coagulation were recorded as the causes of death in those with STAT1 GOF. This evidence concerns the gene STAT1 and hemophagocytic syndrome.