Fourteen patients with STAT1 LOF mutations suffered virus infections, which included EBV (50.0%), VZV (41.7%), HSV (41.7%), CMV (41.7%), HHV (33.3%), RSV (33.3%), adenovirus (25.0%), Molluscum contagiosum/warts (16.7%), and parvovirus (8.3%) (Supplementary Table). Here, STAT1 is linked to viral infectious disease.