Sepsis, disseminated fungal or viral infections, hemophagocytic syndrome, hemorrhage (including intracranial, cerebral, and lung hemorrhage), multiple organ failure, pneumonia, pulmonary embolism, hepatitis, pulmonary hypertension, and disseminated intravascular coagulation were recorded as the causes of death in those with STAT1 GOF. The gene discussed is STAT1; the disease is hepatitis A virus infection.