Response rates to CD38 mAbs are consistently encouraging in myeloma when combined with current standard of care (84, 85), even in the relapsed/refractory setting (80, 81), such that the addition of daratumumab to standard induction therapy (pre-ASCT), and consolidation post-ASCT has recently been reported (86, 87). This evidence concerns the gene CD38 and plasma cell myeloma.