Consistent with the serum findings from SARS-CoV-2 patients, the MC protease genes TPSB2 and TPSAB1 which encode for α- and β-tryptase, respectively, were significantly elevated in lungs from COVID-19 patients, suggesting increased activation of lung MCs in COVID-19 inflammation (Figure 2). The gene discussed is TPSB2; the disease is COVID-19.