Based on the analysis of the expression of m6A methylation regulatory gene in pancreatic Adenocarcinoma and normal tissue data from TCGA and GEO database, a recent study suggested that m6A methylation regulatory gene is related to the prognosis and immune microenvironment of pancreatic Adenocarcinoma, and constructed a m6A-related risk signature: risk score= −0.087 × METTL3 + 0.233 × KIAA1429-0.132 × METTL14-0.035 × YTHDF1-0.0286 × ALKBH5. The gene discussed is YTHDF1; the disease is pancreatic adenocarcinoma.