In addition, in mismatch-repair-proficient or microsatellite instability-low (pMMR-MSI-L) colorectal cancer and melanoma, the deletion of METTL3 and METTL14 increased the infiltration of CD8+T cells and the secretion of IFN- γ, Cxcl9 and Cxcl10, and enhanced the anti-PD-1 response. The gene discussed is PDCD1; the disease is melanoma.