APC and anemia (phenotype): Radulescu et al., who showed in a rodent model that luminal iron cooperates with Apc (adenomatous polyposis coli gene) loss to promote intestinal tumorigenesis, propose that in patients with CRC, a combination of colonic luminal iron chelation and concurrent systemic iron replacement therapy would both resolve anemia and at the same time diminish the carcinogenic pool of residual iron within the colon (174).